Genetic driver events in premalignancy: LOH validated for marking the risk of oral cancer.
نویسنده
چکیده
In this issue of the journal (beginning on page 1081), Zhang and colleagues extend the 30-year-old discovery of LOH profiles to provide validated markers of oral premalignant lesion risk for cancer. They prospectively show a dramatic difference in cancer progression between high-risk lesions (LOH) and low-risk (non-LOH) lesions (P = 0.002). This work has important implications for oral cancer prevention and risk modeling and for understanding genetic driver events in premalignancy.
منابع مشابه
Allelic losses in OraTest-directed biopsies of patients with prior upper aerodigestive tract malignancy.
Genetic alterations at critical chromosome loci have been shown to be predictors of the progression of oral premalignancy-to-invasive cancer. We obtained a unique group of oral biopsies, initially collected during a prospective study designed to test the ability of OraTest (toluidine blue), to identify recurrent oral neoplastic lesions in patients with definite therapy for head and neck or uppe...
متن کاملA Review of Driver Genetic Alterations in Thyroid Cancers
Thyroid cancer is a frequent endocrine related malignancy with continuous increasing incidence. There has been moving development in understanding its molecular pathogenesis recently mainly through the explanation of the original role of several key signaling pathways and related molecular distributors. Central to these mechanisms are the genetic and epigenetic alterations in these pathways, su...
متن کاملCan molecular assessment improve classification of head and neck premalignancy?
The carcinogenic process is multistep and requires the accumulation of multiple genetic alterations in epithelial cells in the upper airway. These alterations allow the cells to obtain growth advantages over other cells and malignant phenotypes. It is believed that carcinogens such as cigarette smoke and alcohol are the major etiological factors for development of HNSCC (1, 2). The concept of f...
متن کاملInfluences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia
Recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. The polymorphisms of genes encoding carcinogen-metabolizi...
متن کاملSerum Antibodies against Helicobacter pylori Neutrophil Activating Protein in Carriers of IL-4 C-590T Genetic Polymorphism Amplify the Risk of Gastritis and Gastric Cancer
Background: Gastric cancer arises, mainly, on an inflammatory background. Helicobacter pylori neutrophil activating (HP-NAP) protein functions as a potent pro-inflammatory mediator. Similarly, IL-4 plays a critical role in the inflammation pathway, the levels of which are altered by C to T transition at position -590 in its promoter region. Here, we have aimed to assess the risk of gastri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer prevention research
دوره 5 9 شماره
صفحات -
تاریخ انتشار 2012